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Xian-Chao Zhang

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Open access Jul 2026

DCAF13: a positive regulator of colon cancer cell proliferation via the AMER2/ Wnt/β-catenin pathway.

In colon cancer cells, DCAF13 regulated adenomatous polyposis coli membrane recruitment 2 (AMER2) through ubiquitination, DCAF13 deletion increased AMER2 expression, which inhibited Wnt/β-catenin activity, suppressing cell proliferation, and this effect was further validated in mice with gut-specific DCAF13 knockout.

Yu-Xin Hua, Jie Gao, Qing Sun et al. · 0 citations

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