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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

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Xian-Chao Cheng

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Open access Oct 2026

In Silico Identification of Rosmarinic Acid as a Putative Natural Product Binder of the PI3Kα Allosteric Site

PIK3CA mutations drive tumorigenesis by activating phosphatidylinositol 3-kinase alpha (PI3Kα). The allosteric inhibitor STX-478 exhibits high selectivity toward PI3Kα and avoids adverse effects such as hyperglycemia. Hyperglycemia is the main reason for the limited clinical application of ATP-competitive PI3Kα inhibit...

Wen-Qing Jia, Yu-Kui Ma, Xian-Chao Cheng et al. · 0 citations

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