Author

Xi-Zhe Sun

2 papers indexed here

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Review Open access Oct 2026

Herbal-derived bioactive compounds in stroke recovery: from neuroprotective mechanisms to clinical evidence and translational challenges

Stroke is a leading cause of death and long-term disability worldwide, driven by pathophysiological processes including excitotoxicity, oxidative stress, neuroinflammation and apoptosis. Current pharmacological and non-pharmacological interventions primarily restore perfusion or support rehabilitation but do not fully...

Xi-Zhe Sun, Jia-Lu Lv, Lan-Xin Gu et al. · Frontiers in Neurology · 0 citations

Open access Jul 2026

Proposed Allosteric Inhibition of Cyclin-Dependent Kinase 4 by a Proline-Derived Acylsemicarbazide Compound with Antiproliferative Activity in Breast Cancer Cells

The identified conformational mechanism provides new insights into the dynamic regulation of CDK4 and suggests that stabilization of transient allosteric states represents a promising strategy for the rational design of next-generation CDK4 inhibitors with the potential to overcome resistance in breast cancer therapy.

Xu Huang, Qing-yang Nian, Xi-Zhe Sun et al. · Pharmaceuticals · 0 citations