Open access
Oct 2026
Receptor-induced activation of MERS-CoV spike revealed by time-course cryo-EM
The Middle East respiratory syndrome coronavirus (MERS-CoV) initiates infection by engaging its host receptor dipeptidyl peptidase 4 (DPP4), which activates the viral spike (S) glycoprotein. However, how receptor binding is structurally coupled to membrane fusion has remained unclear. Here, using cryo–electron microsco...
Ya-Jie Wang, Xi-Yuan Pan, Yuxuan Jiang et al.
· PLoS Pathogens · 0 citations