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Xi-Yuan He

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Review Open access Aug 2026

Gut microbiota-derived metabolites and IL-22 signaling in inflammatory bowel disease: context-dependent regulation of mucosal repair and inflammation

It is proposed that the duration and magnitude of IL-22 exposure, its cellular source, the IL-22/IL-22BP balance, epithelial target-cell state, concurrent inflammatory signals, and disease context collectively determine whether IL-22 promotes mucosal repair or contributes to inflammatory amplification.

Pei-Xin Shi, Xi-Yuan He, Ling Zhao et al. · 0 citations

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