ABSTRACT Developing a safe and effective HIV-1 vaccine remains the cornerstone of global efforts to terminate the AIDS pandemic. However, the virus's immense genetic diversity and the persistent absence of a universal Correlate of Protection (CoP) present formidable barriers. Concomitant with the iterative evolution of...
Hang Yu, Xi Wu, Ting-Ting Li et al.· Emerging Microbes and Infect...· 0 citations
ABSTRACT Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000–2022) using pseudovirus-based neutralization assays and antigenic cartogra...
Yi-Meng An, Mei-Na Cai, Chen-Yan Zhao et al.· Emerging Microbes and Infect...· 0 citations
The successfully developed novel 6-9ΔGΔ51+S226R-H5N1 vaccine candidate not only exhibits excellent safety and immunogenicity but also represents a powerful potential tool for the effective prevention and control of highly pathogenic avian influenza.
Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al.· Signal Transduction and Targ...· 0 citations
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