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Review Open access Oct 2026

Clinical immunogenicity assessment of HIV/AIDS vaccines: current progress and future perspectives

ABSTRACT Developing a safe and effective HIV-1 vaccine remains the cornerstone of global efforts to terminate the AIDS pandemic. However, the virus's immense genetic diversity and the persistent absence of a universal Correlate of Protection (CoP) present formidable barriers. Concomitant with the iterative evolution of...

Hang Yu, Xi Wu, Ting-Ting Li et al. · 0 citations
Open access Sep 2026

Consensus H3N2 HA immunogens incorporating key antigenic mutations elicit broad-spectrum neutralizing responses

ABSTRACT Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000–2022) using pseudovirus-based neutralization assays and antigenic cartogra...

Yi-Meng An, Mei-Na Cai, Chen-Yan Zhao et al. · 0 citations
Open access Sep 2026

Highly efficient intranasal H5N1 vaccine based on a safe vesicular stomatitis virus (VSV) vector

The successfully developed novel 6-9ΔGΔ51+S226R-H5N1 vaccine candidate not only exhibits excellent safety and immunogenicity but also represents a powerful potential tool for the effective prevention and control of highly pathogenic avian influenza.

Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al. · 0 citations

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