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Open access Oct 2026

Integrative single-cell and computational pathology analyses reveal a C11orf24-associated stem-like epithelial population linked to tumor microenvironment remodeling and immune evasion in bladder cancer.

BACKGROUND Cancer stem-like cells drive tumor progression and therapeutic resistance, yet the epithelial stemness hierarchy in bladder cancer (BLCA) remains poorly defined. We aimed to characterize stemness-associated epithelial populations and their clinical significance. METHODS We analyzed single-cell RNA sequenci...

Ying-Jian Wang, Song-Xin Zhang, Xi Luo et al. · 0 citations
Open access Sep 2026

Integrated multi-omics analyses reveal the role of PAXX in colorectal cancer progression and the tumor immune microenvironment

Functional and rescue experiments support MAPK/ERK signaling as a partial mediator of PAXX-associated malignant phenotypes and EMT-related alterations in CRC progression and its association with the tumor immune microenvironment.

Jin-Zhong Cao, Zi-Jing Wang, Xi Luo et al. · 0 citations

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