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Author

Xi-Lin Jiang

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Open access Sep 2026

HIF-1 exerts a double-edged sword regulatory role in hippocampal neuronal PANoptosis of Alzheimer's disease through HK2/VDAC1/NLRP3 axis and RIPK3 signal.

Extensive neuronal loss in brain regions critical for learning and memory is a hallmark of Alzheimer's disease (AD). PANoptosis, a newly characterized form of programmed cell death, integrates the key features of pyroptosis, apoptosis and necroptosis, and explains the molecular crosstalk among these pathways. However,...

Si-Qi Wang, Lai-Xin Luo, Xi-Lin Jiang et al. · 0 citations
Aug 2026

PPARα deficiency exacerbates atherosclerosis progressing through enhancing pTh17 cells-macrophage crosstalk.

Findings establish PPARα as a vital metabolic-immune checkpoint, providing a mechanistic rationale for targeting the PPARα-cGAS-STING axis to concurrently attenuate pathogenic T cell inflammation and stabilize atherosclerotic plaques.

Tong Ren, Xi-Lin Jiang, Jianfeng Wu et al. · 1 citation
Open access Aug 2026

A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries

This study enables study of large-scale proteomics in diverse populations, provides a systematic map of protein associations of cardiovascular diseases, and demonstrates the utility of genetically imputed proteomes for target discovery and experimental validation.

Yu Xu, Douglas P. Loesch, H. Taylor et al. · 0 citations

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