Enhancing the practical applicability of electrochemical biosensors in complex biological fluids hinges on addressing biofouling. Antifouling hydrogels, while effective at resisting nonspecific biomolecule adsorption, are intrinsically insulating, which poses a challenge in reconciling their antifouling capability wi...
Qiu-Shu Du, Rui Han, Xi-Liang Luo· Analytical Chemistry· 0 citations
A facile and versatile antifouling sensor capable of assaying targets in diverse biological fluids was developed based on engineered peptoids with improved proteolytic stability. As peptidomimetics featuring N-substituted glycine backbones, the engineered peptoids are anchored by d-Cys, linked by (d-Pro)4 fragment, a...
Min Chen, Meng-Yan Li, Gui-Xiang Wang et al.· Analytical Chemistry· 0 citations
This study presents a robust and generalizable interface engineering strategy that significantly enhances biosensor antifouling performance and analytical reliability, highlighting its strong potential for clinical monitoring in complex biological environments.
Qiushu Du, Pei-Pei Wang, Zhen Song et al.· Analytica Chimica Acta· 0 citations
A β-d-glucose (β-d-Glc) moiety is introduced at the C-terminus of sensor-integrated peptide sequences to markedly enhance peptide–water interactions, reduce nonspecific adsorption, and protect the peptide backbone from proteolytic cleavage.
Yan-Xin Li, Yinan Zhan, Jie Yang et al.· Chemical Science· 0 citations
A robust antifouling photoelectrochemical (PEC) immunoassay based on a self-assembled peptide hydrogel-engineered Au/SCN/PCN-222 photocathode for sensitive S100B detection exhibited high sensitivity, excellent antifouling performance, and good selectivity, enabling reliable analysis in complex biological matrices.
Feng Xu, Yao-Yao Xiao, Gao-Chao Fan et al.· Analytical Chemistry· 0 citations
An antifouling electrochemical biosensor is constructed, which effectively resists nonspecific adsorption while maintaining high enzymatic stability, enabling the direct detection of carbohydrate antigen 15-3 in human serum with a detection limit of 2.64 mU·mL-1.
Shuyu Jiang, Shi-Cheng Liu, Zhen Song et al.· Analytical Chemistry· 0 citations
The reliable electrochemical detection of immunoglobulin G (IgG) in complex biological fluids is severely hampered by nonspecific protein fouling and enzymatic degradation. Inspired by natural lasso peptides, we engineer a multifunctional lasso-like peptide (LaP) composed entirely of D-amino acids that uniquely integra...
