Xi-Hu Yao

c-MET/NF-κB axis modulates PD-L1 and CCL22-mediated immune evasion and its inhibition enhances anti-PD-1 efficacy in non-small cell lung cancer.

BACKGROUND c-MET overexpression is common in non-small cell lung cancer (NSCLC) and associated with poor prognosis, however, its role in immune evasion and immunotherapy resistance remains unclear. METHODS We analyzed c-MET expression in public "The Cancer Genome Atlas NSCLC" cohort (n = 1043) and an institutional co...