In vivo self-assembly of small RNAs in extracellular vesicles: a commentary on a new therapeutic paradigm
: Extracellular vesicles (EVs) can transport functional RNA, but the clinical development of EV-based RNA therapeutics has been constrained by the technical demands of ex vivo production and cargo loading. A recently reported strategy uses a plasmid to direct the formation of small interfering RNA (siRNA)-containing sm...