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Author

Xi Chen

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Open access Sep 2026

In vivo self-assembly of small RNAs in extracellular vesicles: a commentary on a new therapeutic paradigm

: Extracellular vesicles (EVs) can transport functional RNA, but the clinical development of EV-based RNA therapeutics has been constrained by the technical demands of ex vivo production and cargo loading. A recently reported strategy uses a plasmid to direct the formation of small interfering RNA (siRNA)-containing sm...

Azhar Anwar, Xin Yin, Xi Chen · 0 citations
Open access Aug 2026

Targeted KRAS suppression in colorectal cancer via in vivo self-assembled siRNAs encapsulated in endogenous small extracellular vesicles.

A robust and targeted siRNA delivery system that effectively overcomes the historical limitations of KRAS targeting is established, providing a promising therapeutic strategy for a broad spectrum of KRAS-driven cancers.

Ying Sun, Yixuan Zhao, Yixuan Yang et al. · 0 citations

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