A unified framework for the systematic detection of non-canonical proteins in standard proteomics workflows using a Ribo-seq informed transcriptomic language model
Although ribosome profiling (Ribo-seq) has revealed widespread translation of non-canonical open reading frames (ncORFs), integrating this information into routine mass spectrometry (MS) workflows remains challenging due to biochemical constraints and large search databases. We retrained TIS Transformer, a transcript...
Nicolas Provencher, Sebastien Leblanc, J. Jacques et al.
· Scientific Reports · 0 citations