Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP dimerization modes, the molecular basis underl...
Ye-Qing Du, Tai-Ping Zhou, Wen-Ya Tian et al.· Journal of the American Chem...· 0 citations
This study systematically characterize AntB and uncover its remarkable dual substrate promiscuity, and establishes AntB as a versatile biocatalyst for late-stage natural product diversification.
Meng-Meng Zheng, Yu-Han Dai, Xiang-Yu Li et al.· Angewandte Chemie· 0 citations
3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient microbial cell factory for 3’-SL producti...
Yan Wu, Tao-Ling Min, Zhenfeng Ma et al.· Bioresources and Bioprocessi...· 0 citations
PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.
Yan Gao, Kai Jiang, Yu-Han Dai et al.· Journal of the American Chem...· 0 citations
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