RNA-dependent RNA polymerase (RdRp) is the core catalytic enzyme that mediates RNA viral replication and transcription. The polymerase facilitates template and substrate channel assembly, nucleotide selectivity, and phosphodiester bond formation, making it an essential component of the viral life cycle. RdRps differ gr...
Wei Liu, Yi-Yi Feng, Fan-Xin Liu et al.· Antiviral Research· 0 citations
Protection was accompanied by an increased frequency of splenic CD3 + CD8 + T cells, particularly after booster immunization, suggesting a role for cellular immunity alongside neutralizing antibodies.
Fei Wang, Jia-Nan Xie, Guo-Yuan Wen et al.· Frontiers in Immunology· 0 citations
Using recombinant viruses generated in this study, the effects of the K247 ubiquitination site on host cell metabolism are investigated and indicate that the K247 residue of the NDV M protein enhances viral budding and promotes rapid utilization of host sphingolipids.
Jun Dai, Fan-Xin Liu, Yiyi Feng et al.· Poultry Science· 0 citations
The PLpro-TM protein is identified as a pan-coronavirus antagonist of nucleocytoplasmic trafficking and innate immune response and established PLpro-TM-mediated cleavage of Importin α1 as a conserved immune evasion strategy across coronaviruses and highlights this interaction as a potential target for broad-spectrum an...
Jie-Huang Wang, Wenxiang Xue, Ying-Jie Sun et al.· bioRxiv· 0 citations
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