FOXA1+CD3+T lymphocytes exacerbate myocardial injury in immune checkpoint inhibitor associated myocarditis via the DLL1/Notch1/GSDMD signaling pathway
Immune checkpoint inhibitor-associated myocarditis (ICIAM),through occurring in only 1%-1.4% of patients, carries a mortality rate of up to 60%. Despite this high lethality, its pathogenesis remains poorly understood. While T cell-driven inflammation is a known feature of ICIAM, the key transcriptional regulators...