X. Hong

Single-cell profiling reveals an XBP1s-associated ER proteostasis state linked to metastatic stress adaptation in melanoma.

Metastatic melanoma cells must adapt to matrix detachment and proteotoxic stress during dissemination and colonization, but the stress-adaptive tumor-cell states that support this process remain unclear. Using single-cell RNA sequencing in a B16 melanoma model, we identified a metastasis-enriched ER-stress_tumor state...