Review
Open access
Sep 2026
Immune remodeling of tumor-draining lymph nodes: mechanistic determinants of checkpoint blockade responsiveness
The Review links tdLN structural, cellular, and metabolic remodeling to ICB response and resistance, highlights reinforcement of regulatory circuits after metastatic colonization, and discusses translational strategies that incorporate tdLN functional state into therapeutic design.
Cai-Yan Jia, Shu-Xuan Li, Mu-Hua Chen et al.
· Frontiers in Immunology · 0 citations