Author

Wu-Cheng Yang

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Open access Sep 2026

Clinicopathological Features and Exploratory Outcome Associations of Bone Marrow Fibrosis in Newly Diagnosed Acute Lymphoblastic Leukemia: A Single‐Center Retrospective Cohort Study

ABSTRACT Bone marrow fibrosis (MF) reflects stromal remodeling and has been associated with treatment resistance and adverse outcomes in hematologic malignancies; however, its clinical significance in acute lymphoblastic leukemia (ALL) remains uncertain. We retrospectively analyzed 103 patients with newly diagnosed ALL...

Ying Chen, Si-Heng Liu, Cen-Xia Ran et al. · Cancer Medicine · 0 citations

Case report Open access Sep 2026

Concurrent RUNX1::MECOM and RUNX1::PRDM16 Fusions from a Novel Genomic Breakpoint: First Report of a Dual-Fusion Mechanism in Acute Myeloid Leukemia

Abstract While complex fusions involving three chromosomes are already uncommon in AML, the formation of two distinct fusion genes from an identical breakpoint is exceptionally rare. This paper reports the adult case of acute myeloid leukemia harboring dual fusion genes RUNX1::MECOM and RUNX1::PRDM16, both originating...

Si-Yu Chen, Sheng-Wang Wu, Jing Zhang et al. · OncoTargets and Therapy · 0 citations

Open access Sep 2026

Paeoniflorin prevents acute graft-versus-host disease while preserving graft-versus-tumor effects

Findings support PF as a potential prophylactic candidate for allo-HSCT through coordinated regulation of donor T cell responses, inflammatory mediators, hematopoietic reconstitution, intestinal barrier injury, apoptosis, and gut microbiota, while preserving GVT activity.

Xing-Yu Wan, Nan Li, Yang Gou et al. · Frontiers in Immunology · 0 citations