Leaky expression of PRMT1 in Escherichia coli and redox regulation of its histone methyltransferase activity
Protein arginine methyltransferase 1 (PRMT1) is a major histone and non-histone arginine methyltransferase whose activity is important for gene regulation and genome stability. In this study, we investigated how expression conditions and redox environment affect recombinant human PRMT1 produced in Escherichia coli BL21...