Author

Wolfgang W. A. Schamel

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Open access Aug 2026

The Y105 phosphosite between the SH3.1 and SH3.2 domains of Nck1 regulates its binding to CD3ϵ

Summary In αβ T cells, ligand binding to T cell receptor (TCR) triggers conformational changes at CD3ε subunits to expose the proline-rich sequence (PRS), which binds to the non-catalytic region of tyrosine kinase (Nck) via its Src homology 3 (SH3).1 domain. Recruitment of Nck to CD3ε initiates phosphorylation of vario...

Jatuporn Ngoenkam, Piyamaporn Wipa, Pussadee Paensuwan et al. · iScience · 0 citations

Open access Aug 2026

USP8 controls proteostasis pathways in B cells and multiple myeloma.

Ubiquitin-specific protease 8 (USP8) plays a pivotal role in the regulation of endosomal and lysosomal trafficking and is critically involved in the pathogenesis of various tumor entities. USP8 represents a vulnerability gene in multiple myeloma (MM), suggesting a functional role in the B- and plasma cell compartment....

Almut Dufner, Fabien Théry, G. Monaco et al. · Leukemia · 1 citation

Open access Aug 2026

Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota

The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages—both of which play critical roles in immune surveillance, barrier integrity, and tissue homeostasis. While their feta...

D. Obwegs, Alexander Oschwald, L. Koetter et al. · Science Advances · 0 citations