The nociceptor-CGRP-lactate axis in cancer immune escape: linking neural signaling, immunometabolism, and immunotherapy resistance.
Cancer neuroscience has expanded the conceptual landscape of tumor biology by revealing that nerves are not passive bystanders within malignant tissues, but active regulators of tumor progression, immune surveillance, and therapeutic response. Among neural components of the tumor microenvironment, nociceptive sensory n...