Author

Willow Coyote-Maestas

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Open access Oct 2026

Distinct activation mechanisms underlie ligand efficacy at a GPCR

A deep mutational pharmacology approach is developed to measure how each residue in the µ-opioid receptor (µOR) shapes responses to 15 opioids, yielding ∼400,000 measurements of variant effects on signaling and expression, including full concentration-response series for three agonists.

Matthew K. Howard, Eve J. Fine, Karthik Srinivasan et al. · bioRxiv · 0 citations

Open access Sep 2026

Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis

Hundreds of mutations to the broadly expressed LMNA gene cause disease primarily within cardiac, muscular, and adipose tissues1. Tissue-specific pathogenesis arises when mutant protein dysfunction collides with the unique demands of a specific cell type. Here, we decipher the cell-type-specific consequences of ∼15,000...

Jessica Mella, Abigail E. Hein, Navraj Lally et al. · bioRxiv · 0 citations

Open access Aug 2026

Efficient experimental characterization of the GPCRome via deep receptor scanning

A versatile “deep receptor scanning” platform is introduced that can be used to experimentally characterize 766 human GPCRs and 174 known GPCR splice variants in parallel and show that many highly-expressed receptors exhibit systematic differences in hydrophobicity and secondary structure.

A. Tedman, Muskan Goel, Sohan S. Shah et al. · Nature Communications · 0 citations