Dark proteome ensemble superposition gating calibrates biosynthesis of antiviral cocktail
Intrinsically disordered regions (IDRs)-the proteome dark matter-confer dynamic adaptability upon rigid protein scaffolds. How IDRs and their adjacent folded domain (context) modulate enzyme substrate promiscuity and calibrate host-specific immune outputs remains unknown. Addressing this knowledge gap has substantial e...
Meng-Di Wu, Denise Poire, Hannah Florance et al.
· bioRxiv · 0 citations