A comprehensive cell fate map of mammalian embryogenesis has remained out of reach given the scale, cellular diversity, and non-deterministic nature of development in utero. Here, we use PEtracer to continuously install heritable genetic marks as development progresses, reconstructing lineage trees that resolve ∼75% of...
William N. Colgan, Luke W. Koblan, JoAnne Villagrana et al.· Cell· 2 citations
Tumor progression is driven by dynamic interactions between cancer cells and their surrounding microenvironment. Here we integrate high-resolution spatial transcriptomics and evolving lineage-tracing technologies to elucidate how tumor expansion, plasticity and metastasis co-evolve with microenvironmental remodeling in...
Matthew G. Jones, Da-Wei Sun, Kyung Hoi (Joseph) Min et al.· Nature Genetics· 0 citations
Reconstructing clonal relationships among human cells is fundamental to understanding development, aging, and disease. Somatic mitochondrial DNA (mtDNA) mutations act as endogenous single-cell barcodes measurable alongside cell-state profiles, but lineage tracing has traditionally focused on high-heteroplasmy variants,...
Chen Weng, T. Gao, William N. Colgan et al.· bioRxiv· 0 citations
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