Fluorescent imaging in live cells is a cornerstone of life sciences. While natural fluorescent proteins have been engineered to enhance individual features, no existing tag combines ideal properties into a single system: high brightness, reversible binding, compact size, and stability across diverse conditions. Here, w...
Yu-Da Chen, Klaus Yserentant, Kibeom Hong et al.· Cell· 0 citations
Proton-coupled electron transfer (PCET) reactions mediate essential biological energy-conversion processes, yet dynamical experiments that distinguish concerted electron/proton motion from sequential electron-transfer/proton-transfer pathways are unprecedented on ultrafast time scales. Here we report a tightly coupled...
Rui Liu, Zachary X. W. Widel, Jia-Qi Zhu et al.· Journal of the American Chem...· 1 citation
Testing the ability of common large language models to consider design principles to generate de novo proteins that bind metals and lipophilic small molecules without copying existing sequences highlights the utility of LLMs in making protein design more comprehensible and accessible to users without sophisticated desi...
Nam Hyeong Kim, A. K. Hatstat, Hyunil Jo et al.· bioRxiv· 1 citation
The de novo design of proteins that bind chemically complex small molecules has broad chemical and biological implications, but strategies typically rely on a small set of protein scaffolds and require extensive experimental screening. Here, we computationally designed proteins around a minimal aromatic π-stacking moti...
S. Ouchida, Maggie Horst, Xuxu Gou et al.· bioRxiv· 0 citations
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