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Open access Aug 2026

Porcine coronavirus promotes NLRP3 inflammasome activation during virus-induced neuroinflammation

ABSTRACT Neurotropic coronaviruses can invade the central nervous system (CNS) and cause severe neurological disease, but the mechanisms underlying virus-induced neuroinflammation remain incompletely understood. Here, we report that infection with porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic b...

Qianyu Zhou, Junchao Shi, Ruizhao Qiu et al. · 0 citations
Aug 2026

An engineered oncolytic parapoxvirus induces immunogenic tumor cell death and displays antitumor efficacy by enhancing T cell responses.

These findings establish ORFVΔ-IL15 as a novel therapeutic agent that integrates oncolytic and immunoregulatory functions, demonstrating robust tumor-suppressive efficacy and offering a promising strategy for next-generation oncolytic virus engineering.

Qi Li, Jing Lin, Fei Gao et al. · 0 citations

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