Open access
Jul 2026
Blocking the m6Am methyltransferase PCIF1 releases STAT1-mediated Th1 immunity to potentiate cancer immunotherapy
It is shown, by genomic deletion of PCIF1 specifically in T cells, that PCIF1 represses STAT1 translation via this important mRNA modification, and thereby preventing T cell activation and enforcing a naïve T cell phenotype.
Jian-Song Huang, Jing Zhou, Xiao Liu et al.
· Nature Communications · 1 citation