Single-Cell Transcriptome Analysis Reveals IRF1-Driven Epithelial States and Glycosaminoglycan–Glycolysis Coupling in Cisplatin-Resistant HGSOC
Objectives Cisplatin resistance is the principal cause of relapse in high-grade serous ovarian cancer (HGSOC), but bulk-expression signatures cannot localize resistant malignant states or the tumor–microenvironment (TME) interactions that sustain them. This study aimed to define cisplatin-resistant epithelial cell stat...