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Author

Wenjie Tian

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Review Open access Jul 2026

Reader-dependent functional duality of FTO: a context-switching node at the intersection of immune evasion and therapeutic resistance

The fat mass and obesity-associated protein (FTO), an RNA demethylase acting on both internal m6;A and cap-proximal m6;Am, functions in cancer as a context-dependent epitranscriptomic regulator whose net effect cannot be reduced to an oncogene–tumor-suppressor dichotomy. Its biological output is shaped by tumor lineage...

Wenjie Tian, Bin Xie, P. Zhan · 0 citations
Review Open access Jul 2026

O-GlcNAcylation at the tumor–immune interface: a metabolic post-translational code driving immune evasion and therapy resistance in cancer

Protein O-GlcNAcylation has evolved from a metabolic curiosity into a master post-translational modification that enables cancer cells to translate nutrient availability into coordinated programs of proliferation, therapy resistance, and immune evasion. In this review, we argue that hyper-O-GlcNAcylation is not merely...

Shan-Shan Liu, P. Zhan, Wenjie Tian et al. · 0 citations

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