Author

Wen-Zheng Wang

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Open access Aug 2026

Mitochondrial stress activates ELT-2–dependent lysosomal proteostasis to extend lifespan in C. elegans

It is shown that inhibition of mitochondrial respiration induces a sustained transcriptional program that enhances lysosomal proteolysis during aging in Caenorhabditis elegans and reveals a previously unrecognized ELT-2–dependent lysosomal proteostasis pathway that acts downstream of mitochondrial stress to maintain pr...

Rendan Yang, Yu Sun, Wen-Zheng Wang et al. · Science Advances · 0 citations

Open access Aug 2026

iDCF: Interpretable deconvolution of cell fractions via biologically-informed deep learning using scRNA-seq data

iDCF (Interpretable Deconvolution of Cell Fractions) is a novel framework that enforces biological topology onto deep neural networks, bridging the gap between computational inference and biological intuition.

Hongming Guo, Ting-Fang Wu, Wen-Zheng Wang et al. · PLoS Computational Biology · 0 citations