Open access
Aug 2026
Pannexin 1 drives cardiac fibroblast activation and fibrosis via the ATP-purinergic receptor-JAK2/STAT3 axis in heart failure.
In vivo injection of a PANX1 blocker provides evidence for the role of Panx1 in alleviating cardiac fibrosis and bioinformatics analysis suggests that this process is associated with the JAK/STAT signaling pathway.
Lieyang Qin, Yunjing Zhang, Diyaerjiang Aierken et al.
· Acta Biochimica et Biophysic... · 0 citations