RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative model that learns a conditionable design grammar from RNA sequences, experimental structural probing profiles, and functiona...
It is demonstrated that SF3B1 undergoes intrinsic, IDR‐driven liquid‐liquid phase separation both in vitro and in vivo, forming nuclear condensates in oocytes and early embryos, which is essential for successful development to the blastocyst stage.
Kang Zhao, Ting-Yu Han, Yan-Li Cheng et al.· Advancement of science· 0 citations
An automated bioreactor was utilized that supported long-term differentiation of human embryonic stem cells into human induced primordial germ cells, human induced ovarian follicles, and human induced spermatogonial stem cells aboard spacecraft and demonstrated preserved genomic integrity despite these functional pertu...
Ying Li, Hui Gao, Jie Xiong et al.· Science Advances· 0 citations
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