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Oct 2026

MicroRNA-145 hinders carotid plaque growth via suppression of tumor growth factor-β receptor type II and autophagy.

Plaque erosion is increasingly recognized as a critical pathological mechanism in acute coronary syndrome. In this study, we found that microRNA-145 (miR-145) levels were significantly reduced in plaques with grade III-IV stenosis compared with controls. Using an apoE-/- mouse model fed a high-cholesterol diet, we demo...

Yun-Juan Jiao, Gao-En Ma, Jun-Kai Ma et al. · 0 citations
Review Open access Oct 2026

Recent advances in cancer-associated fibroblasts in colorectal cancer: functional subtypes, spatiotemporal dynamics and therapeutic targets.

Colorectal cancer (CRC) is a malignant tumour with an extremely high global incidence rate; its development and progression are closely linked to fibroblasts within the tumour microenvironment (TME). In recent years, single-cell and spatial multi-omics technologies have revealed the high heterogeneity of fibroblasts in...

Yuang Ding, Shao-Hui Zhang, Yan-Feng Guo et al. · 0 citations
Review Open access Sep 2026

Mitochondria-associated programmed cell death in colorectal cancer: molecular mechanisms, metabolic plasticity, and therapeutic opportunities.

Mitochondria integrate bioenergetics, redox homeostasis, calcium signaling, metabolite synthesis, organelle quality control, innate immune sensing, and regulated cell death. In colorectal cancer (CRC), mitochondrial function is not simply suppressed by aerobic glycolysis; rather, tumor cells dynamically redistribute fl...

Shao-Jie Liu, Jia-Qi Zhang, Zi-Han Zhang et al. · 0 citations

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