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Open access Oct 2026

SEEKER: A genome-scale library-on-library screening platform for deciphering T cell recognition of antigen

Decoding which antigens activate a given T cell receptor (TCR) is a central challenge in immunology. We present SEEKER, a functional genome-scale library-on-library screening platform built on three elements: a Jurkat-derived T-APC cell (TAPCell) that combinatorially expresses one TCR and one peptide–MHC drawn from sep...

Si-Cheng Li, Li Lin, Wen-Xu Wu et al. · 0 citations
#artificial intelligence Preprint Sep 2026

GFD-OPD: Guidance-Folded On-Policy Distillation of Diffusion Models Across Scales

On-policy distillation (OPD) has demonstrated two important capabilities in language models: compressing large teachers into smaller students and merging expert models into a single model. Existing diffusion OPD, however, mostly focus on the latter, with teachers and students sharing the same backbone and scale. We inv...

Zhen-Xing Zhang, Jia-Yan Teng, Wen-Xu Wu et al. · 0 citations

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