Open access
Sep 2026
Development and Humanization of a Camelid-Derived Neutralizing Nanobody Targeting Botulinum Neurotoxin Type A
Purpose Botulinum neurotoxin (BoNT), produced by Clostridium botulinum, is one of the most potent neurotoxins, causing botulism, a potentially fatal paralytic disease. Among different serotypes, BoNT/A is the most potent and the primary cause of botulism. The receptor-binding domain (Hc) of BoNT is crucial for targetin...
Yu-Jia Jiang, Wen-Wen Xin, Jian-Sheng Lu et al.
· International Journal of Nan... · 0 citations