Structural basis for the broad-spectrum inhibition of the coronavirus main protease by Zevotrelvir.
Beta-coronaviruses have caused three major coronavirus outbreaks, underscoring the urgent need for broad-spectrum antivirals. The coronavirus main protease (Mpro) is an ideal drug target due to its high conservation and absence of human homologs. Zevotrelvir (EDP-235) is an oral Mpro inhibitor with broad-spectrum activ...