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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Wenwen Jin

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2 papers indexed here

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Open access Sep 2026

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad-spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity an...

P. Zanvit, Jun-Ji Xu, Wen-Jing Yang et al. · 0 citations
Open access Aug 2026

Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy

It is shown that anti-CTLA-4 antibody engages CTLA-4 in Tregs specifically in the tumor tissues to reduce their stability and survival and weaken their suppressive function through upregulating TGF-β signaling, which leads to the antibody-mediated - upregulation of CD4+ and CD8+ effector T cell anti-tumor immunity and...

Na Liu, Jun-Ji Xu, Wai Lim Ku et al. · 0 citations

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