Author

Wen-Wan Zhang

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Open access Sep 2026

LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation

Mechanical adaptation is a fundamental yet poorly understood process in stromal tissue biology. Here, we identify a population of LGR5+ mechanically induced regulatory fibroblasts (LGR5+ MIRFs) in mouse and human dermis, whose induction requires a YAP/AP-1-dependent transcriptional program. LGR5+ MIRFs channel mechanic...

Qiao-Yu Fu, Xi Cheng, Nuo Chen et al. · Nature Communications · 0 citations