Wen-Qing Zhang

Mechano-metabolic coupling in the tumor microenvironment: from mechanotransduction to protein lactylation and metastatic cascades

Aberrant mechanical signals within the tumor microenvironment (TME)—including increased extracellular matrix stiffness, elevated solid stress, heightened interstitial fluid pressure, and fluid shear stress—have been established as key drivers of malignant tumor progression and metastasis. These physical cues are sensed...