Author

Wen-Qian Zhao

2 papers indexed here

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Open access Oct 2026

ITGB2 promotes HIF-1α/GLUT1 mediated glucose metabolic reprogramming in renal tubular epithelial cells to aggravate the progression of diabetic kidney disease

Diabetic kidney disease (DKD) is characterized by tubular metabolic remodeling, inflammation, and profibrotic injury. However, whether integrin β2 (ITGB2) links high-glucose (HG) stress to hypoxia-inducible factor-1α (HIF-1α)/glucose transporter 1 (GLUT1)-dependent metabolic reprogramming in renal tubular epithelial ce...

Jun Peng, Qiao-Meng Yuan, Lu Zhou et al. · Cytotechnology (Dordrecht) · 0 citations

Open access Sep 2026

Mitochondrial dysfunction drives metabolic reprogramming in Gitelman syndrome: insights from proteomics and isogenic modeling

The integrated multi-omics and functional approach establishes a strong association between the SLC12A3 p.C421F mutation and a state of mitochondrial bioenergetic failure—characterized by impaired oxidative phosphorylation, an ATP deficit, and a compensatory metabolic shift towards glycolysis—in GS.

Hong-Han Zhang, Wen-Qian Zhao, Lan-Xin Ma et al. · Human Genetics · 0 citations