Nov 2025
Vitamin B12 alleviates spliceosomopathy via phospholipid remodeling
A mechanistic connection between RNA splicing and lipid metabolism is established, implicating VB12-dependent one-carbon metabolism as a metabolic modulator with broad implications for spliceosome-related diseases, and suggesting VB12 as a potential strategy to mitigate VRJS-related anomalies.
A. Antebi, Wen-Ming Huang, Jonathan Kölschbach et al.
· Research Square · 0 citations