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Wen-Lei Zhao

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Open access Oct 2026

The KLF4–SLC25A4 mitochondrial axis regulates ferroptotic vulnerability and sunitinib sensitivity in clear cell renal cell carcinoma

Sunitinib resistance remains a major therapeutic challenge in clear cell renal cell carcinoma (ccRCC). Through integrated transcriptomic profiling and mitochondrial gene screening, we identified SLC25A4 as a ferroptosis-associated tumor suppressor. SLC25A4 expression was significantly downregulated in ccRCC tissues a...

Shuo Tian, Hai-Rui Chen, Wen-Lei Zhao et al. · 0 citations

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