The mechanism of SOX4/IGF2BP3/TRIB3 axis inhibiting autophagy and aggravating liver injury in sepsis.
It was found that the SOX4/IGF2BP3/TRIB3 axis was upregulated in septic hepatocytes, and its knockdown alleviated LPS-induced injury and impaired autophagic flux, and this axis exacerbated LPS-induced hepatocyte injury by suppressing autophagic flux.