Author

Wen-Hui Liu

3 papers indexed here

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Oct 2026

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome.

Onco-fetal reprogramming of the tumor ecosystem induces fetal-like characteristics, leading to tumor growth and malignant progression. Here, we develop a robust computational pipeline to systematically identify onco-fetal (OF) cells, using single-cell transcriptomic data from corresponding fetal and tumor tissues acros...

Yong-Le Xu, Shao-Yi Chen, Zheng-Lin Lu et al. · Genome Research · 0 citations

Open access Aug 2026

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Extracellular vesicles (EVs) from immune cells represent a novel drug delivery system with inherent anti‐tumor properties. To remodel the immunosuppressive tumor microenvironment and mediate multimodal therapy, we produced neutrophil nanovesicles at high yield and loaded them with drug (doxorubicin, DOX), near‐infr...

Jia-Hui Zhang, Cheng Ji, Xin-Jian Fang et al. · Advanced Functional Material... · 0 citations

Sep 2026

Functionalized neutrophil nanovesicles for targeted photodynamic immunotherapy and potentiation of checkpoint blockade in colorectal cancer.

Colorectal cancer (CRC) patients with microsatellite-stable tumors typically resist immune checkpoint blockade (ICB) due to an immunosuppressive "cold" microenvironment. Photodynamic therapy (PDT) generates reactive oxygen species (ROS) to ablate tumor cells and induce immunogenic cell death (ICD), potentiating antitum...

Yuan Zhong, Jia-Hui Zhang, Yu Qian et al. · Nanoscale · 0 citations