Wen-Chen Du

Blunted Lsm14b activation disrupts maternal mRNA remodeling during the GV-to-MII transition in a mouse model of polycystic ovary syndrome

Introduction Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility and is consistently associated with poor oocyte developmental competence, yet the molecular basis of this qualitative defect remains poorly defined. Because the germinal vesicle (GV)-to-metaphase II (MII) transition occurs und...