Author

Wenchao Wang

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Aug 2026

AI-Guided Discovery of Natural-Product-Inspired Scaffolds as Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance.

The utility of AI-guided molecular design for overcoming MDR is demonstrated and a promising natural-product-inspired chemotype for dual P-gp/BCRP inhibitor is established.

Le-Yi Ying, Xin Yu, Lei Li et al. · Journal of Medicinal Chemist... · 0 citations

Jul 2026

Soluplus®-based solid dispersion enhances oral bioavailability of A10: a cGAS-STING and ICD activator for bladder cancer therapy.

Evidence of the immune activation induced by A10 against BCa T24 cells is provided, and A10 could activate the cGAS-STING pathway, promote DAMPs release, and induce Immunogenic Cell Death (ICD) for anti-tumor activity against BCa cells in vitro.

Wenchao Wang, F. Dong, Junrong Lei et al. · International journal of pha... · 0 citations