Author

Wen-Bing Yin

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Open access Aug 2026

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

ABSTRACT Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. In this study, we put forward a novel antifungal strategy that targets the conserved global secondary metabolic pathway in pathogenic...

Zili Song, Can Zhao, Qiaoling Wang et al. · Advancement of science · 0 citations

Open access Aug 2026

A portable pathway specific transcription factor-promoter circuit enables heterologous production of fungal nonribosomal peptides

Most fungal nonribosomal peptide synthetase (NRPS) biosynthetic gene clusters remain transcriptionally silent, severely restricting the discovery of bioactive peptide metabolites. Standard constitutive promoters fail to support robust expression of large multidomain NRPS enzymes. Here, we identify a conserved subgroup...

Peng-Lin Wei, Yuanyuan Li, Zedong Ren et al. · Chemical Science · 0 citations