Multiple instance learning (MIL) is widely used for weakly supervised whole slide image (WSI) analysis. However, under long-tailed distributions, MIL-based WSI analysis faces a nested dual long-tail: an inter-slide class long tail and an intra-slide long tail of instance-level discriminative evidence. The two long tails are coupled: tail classes have few training slides, while their limited diagnostic evidence is concentrated in a few patches and obscured by abundant within-bag redundancy. This coupling biases models toward head classes and degrades rare-class recognition. To address this, we propose DeCo-MIL for long-tailed WSI analysis, which jointly alleviates the nested dual long-tail through frequency-debiased counterfactual reasoning. For the inner long tail, DeCo-MIL clusters patches into tissue-morphology anchors, replaces each anchor with its matched normal prototype to perform a counterfactual intervention, and estimates its counterfactual contribution to the ground-truth class using class-frequency-corrected predictions. These contributions guide redundancy masking to preserve scarce discriminative instances. For the outer long tail, DeCo-MIL constructs anchor-stratified pseudo-bags from redundancy-reduced bags and combines tail-aware oversampling with consistency regularization, increasing effective supervision for tail classes while preserving tissue-morphology composition. Extensive experiments on three long-tailed WSI benchmarks demonstrate that DeCo-MIL achieves state-of-the-art performance in both tail-class recognition and overall classification.
Xiaoxiao Li, Xitong Ling, Jiawen Li et al.· 0 citations
Text-to-image diffusion models have achieved remarkable success in generating high-quality images from a given text prompt. Subject-driven generation aims to synthesize customized images to mimic the appearance of subjects in given reference images within different visual contexts specified by the text prompts. The central challenge here is that, when the reference image changes, the diffusion model cannot efficiently adapt to different visual contexts while consistently maintaining the subject identity. Existing methods either train the model with a large domain-specific dataset or fine-tune the model using the reference image for hundreds of iterations before actual image generation. In this work, we explore a new approach, called \textit{In-Loop Model Adaptation} (IMA), which adapts the core diffusion model at each generation step during the actual process of image generation, without being trained on the reference image before the generation process. To this end, we establish a DDIM inversion chain that maps the reference image to a sequence of latent, as well as a text-to-image generation chain which generates the image from the text prompt only. We then introduce a masked latent consistency loss and a noise regularization loss to characterize the latent-noise difference between the diffusion model and these two chains at each generation step. This coupled latent-noise loss is used to guide the in-loop model adaptation to preserve the subject identity specified by the reference image while maintaining accurate alignment with the text prompt, resulting in high-fidelity text-to-image generation. Our extensive experiments demonstrate that our proposed IMA method significantly improves the performance of subject-driven text-to-image generation.
Yushun Tang, Weiming Chen, Siyi Liu et al.· IEEE transactions on multime...· 0 citations
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