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Open access Sep 2026

Dequalinium chloride promotes the killing efficacy of aminoglycoside antibiotics against Pseudomonas aeruginosa by enhancing membrane potential

ABSTRACT Dequalinium chloride is a dicationic amphiphilic quaternary ammonium compound that is used as an anti-infective drug. Here, we found that it potentiates bactericidal efficacies of aminoglycoside antibiotics against Pseudomonas aeruginosa. Dequalinium chloride increases respiratory activity and bacterial membra...

Xiao-Ya Wei, Zhong-Hui Yang, Yu-Jie Zhang et al. · 0 citations
Open access Sep 2026

TypA Interacts with ExsA to Suppress Type III Secretion System in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a nosocomial pathogenic bacterium that causes a wide range of human infectious diseases. The type III secretion system (T3SS) serves as a key virulence determinant underlying the pathogenesis of this bacterium in acute infections. As the master transcriptional activator of T3SS, ExsA binds to...

Li-Wen Yin, Yi-Ming Li, Xue-Tao Gong et al. · 0 citations

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