Author

Weibin Wang

3 papers indexed here

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Aug 2026

An IRAK1-snRNA axis activates ATM to promote accurate repair within transcriptionally active chromatin.

Genomic integrity in transcriptionally active regions is pivotal for suppressing oncogenic mutations, yet the mechanisms that govern precise homologous recombination (HR) repair within these regions remain elusive. Here, we report that the IRAK1-spliceosome axis operates with small nuclear RNA (snRNA) as a central hub,...

Chen Nie, Wan-Chang Liu, Lei Zhang et al. · Molecules and Cells · 0 citations

Review Open access 2026

RAD51 in homologous recombination-mediated DNA damage repair and genome stability: Mechanisms, regulation and implications for disease

Homologous recombination (HR) is a high-fidelity DNA repair pathway that preserves genome stability through the accurate repair of DNA double-strand breaks. RAD51 is the central recombinase of HR and catalyzes the key processes of homology search and strand invasion through the formation of nucleoprotein filaments on s...

Tao Zhou, Yilin Cui, Xinxin Liang et al. · Ageing and Cancer Research &... · 0 citations

Open access Aug 2026

A regulatory adaptor for RAD51's AAA+ unfoldase promotes homologous recombination-mediated DNA repair and genome stability.

DNA double-strand breaks, including those arising from DNA interstrand crosslinks, are highly cytotoxic forms of DNA damage. Their precise repair by homologous recombination (HR) is essential for maintaining genomic stability. During HR, timely disassembly of the core machinery, RAD51 nucleoprotein filaments, is critic...

Tao Zhou, Ming Pang, Xinxin Liang et al. · Proceedings of the National... · 0 citations